An experimental model might shed new light on the development of brain cancer in children
Pediatric high-grade glioma is the primary cause of cancer death in children. Genesis of these tumors is believed to be driven by mutations in proteins that disrupt fundamental mechanisms governing the development of the human brain. However, our understanding of these tumors remains incomplete due to the lack of faithful experimental models. Now, researchers of the German Center for Neurodegenerative Diseases (DZNE) together with colleagues from Canada and the UK present in the journal “Cancer Cell” a novel laboratory model that replicates key hallmarks of this disease. Results might pave the way for a better understanding of processes, relevant for both cancer and neurodegeneration.